Corthe Dermo Bright Spot LumedicCorthe Dermo Bright Spot Lumedic is a highly concentrated spot treatment targeting stubborn hyperpigmentation. With consistent use, Spot Lumedic helps to suppress overactive melanocyte activity which contributes to hyperpigmentation. The combination of the below tyrosinase inhibitors is what makes this product so effective: Niacinamide: Niacinamide has been shown to inhibit tyrosinase, which helps reduce melanin production and can improve skin tone by